Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts

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KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization.

Hyaluronan (HA) has an extraordinarily high turnover in physiological tissues, and HA degradation is accelerated in inflammatory and neoplastic diseases. CD44 (a cell surface receptor) and two hyaluronidases (HYAL1 and HYAL2) are thought to be responsible for HA binding and degradation; however, the role of these molecules in HA catabolism remains controversial. Here we show that KIAA1199, a de...

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Objective: HYBID (Hyaluronan Binding Protein Involved in HA Depolymerization, KIAA1199) is a hyaluronan (HA) binding protein, which involves in depolymerization of HA. It is reported that HYBID mRNA is expressed in the lung, heart, skin and brain in murine and human. However, the role of HYBID in the brain remains unclear. In this study, we have made HYBID KO mice and evaluated its function in ...

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Objective: HYBID (Hyaluronan Binding Protein Involved in HA Depolymerization, KIAA1199) is a hyaluronan (HA) binding protein, which involves in depolymerization of HA. It is reported that HYBID mRNA is expressed in the lung, heart, skin and brain in murine and human. However, the role of HYBID in the brain remains unclear. In this study, we have made HYBID KO mice and evaluated its function in ...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 2015

ISSN: 0021-9258

DOI: 10.1074/jbc.m115.673566